Aim: The aim of this systematic review is to identify, describe and synthesize evidence from experimental studies conducted to measure and conceptualize self-efficacy within the context of nursing education and the transition of nursing students to prac-tice as a registered practitioners.Design: Systematic review.Methods: Papers were screened by four independent reviewers, and data were ex-tracted using a standardized data extraction tool. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance and checklists were used to guide this review.Results: The review included 47 studies, using a quasi-experimental pre-test–post- test design (n= 39) and randomized control trials (n= 8). Various teaching and learning interventions were used to enhance self-efficacy; however, there is no definitive con-clusion to be drawn regarding the most effective educational interventions. Various instruments were used in the studies to measure self-efficacy. 10 of these were re-lated to general self-efficacy, while 37 instruments measured self-efficacy in the con-text of specific skills.