Horgan, M, O'Flynn, G, Garry, J, Cooney, J, Coffey, A, Fitzgerald, GF, Ross, RP, McAuliffe, O;

2009

February

Applied and Environmental Microbiology

Phage Lysin Lysk Can Be Truncated to Its Chap Domain and Retain Lytic Activity Against Live Antibiotic-Resistant Staphylococci

Validated

()

75

3

872

874

A truncated derivative of the phage endolysin LysK containing only the CHAP ( cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells..

DOI 10.1128/AEM.01831-08