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Firth, AE, Atkins, JF;
2008
July
Archives of Virology
Bioinformatic Analysis Suggests That A Conserved Orf In The Waikaviruses Encodes An Overlapping Gene
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The genus Waikavirus belongs to the order Picornavirales, whose members all use a polyprotein expression strategy. With the exception of Theiler's virus, overlapping genes are essentially unknown in the order. Recently, we reported experimental verification for a new short overlapping coding sequence (CDS) in the Potyviridae-a family in which overlapping genes were previously unknown. Using the same bioinformatics software (MLOGD), we have identified an similar to 89-codon conserved open reading frame (ORF) with a strong coding signature in members of the genus Waikavirus. The ORF overlaps the polyprotein ORF but is in the +1 reading frame. Here, we describe the bioinformatic analysis..
DOI 10.1007/s00705-008-0119-5
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