Peer-Reviewed Journal Details
Mandatory Fields
Leonard, S. A.,Lydon, A.,Walsh, M.,Fleming, C.,Boylan, J.,Shorten, G. D.;
2001
British Journal of Anaesthesia
Does prior administration of enoxaparin influence the effects of levobupivacaine on blood clotting? Assessment using the Thrombelastograph((R))
Validated
()
Optional Fields
86
66
808
813808
The low molecular weight heparin, enoxaparin (by inhibition of factors Xa and Ila) and amide local anaesthetics (by altering platelet function) exert anti-clotting effects. Although these agents are often used in combination during the perioperative period. their potential interactive effect on clotting has not been defined. Blood from 10 ASA I-II patients who received enoxaparin 0.5 mg kg(-1) s.c. was studied using a Thrombelastograph (TEG((R))) either alone or in combination with levobupivacaine (2.5 mg ml(-1) or 2.5 mug ml(-1)) or saline (50% dilution). in blood from patients who had received enoxaparin 0.5 mg kg(-1) s.c. 12 h previously, levobupivacaine 2.5 mg ml(-1) (but not 2.5 mug ml(-1)) produced significant changes in TEG clotting parameters (mean (SD) 15.7 (4.8) mm, 29.6 (25.6) mm, 34.4(14.6) mm, 34.3 (12.2)degrees compared with control values of 6.1 (1.3) mm, 2.5 (0.5) mm, 63.5 (6.4) mm and 74.1 (2.9)degrees for r, K, MA, and a angle respectively).The low molecular weight heparin, enoxaparin (by inhibition of factors Xa and Ila) and amide local anaesthetics (by altering platelet function) exert anti-clotting effects. Although these agents are often used in combination during the perioperative period. their potential interactive effect on clotting has not been defined. Blood from 10 ASA I-II patients who received enoxaparin 0.5 mg kg(-1) s.c. was studied using a Thrombelastograph (TEG((R))) either alone or in combination with levobupivacaine (2.5 mg ml(-1) or 2.5 mug ml(-1)) or saline (50% dilution). in blood from patients who had received enoxaparin 0.5 mg kg(-1) s.c. 12 h previously, levobupivacaine 2.5 mg ml(-1) (but not 2.5 mug ml(-1)) produced significant changes in TEG clotting parameters (mean (SD) 15.7 (4.8) mm, 29.6 (25.6) mm, 34.4(14.6) mm, 34.3 (12.2)degrees compared with control values of 6.1 (1.3) mm, 2.5 (0.5) mm, 63.5 (6.4) mm and 74.1 (2.9)degrees for r, K, MA, and a angle respectively).
0007-09120007-0912
://WOS:000169141300012://WOS:000169141300012
Grant Details