Peer-Reviewed Journal Details
Mandatory Fields
Tangney, M.*,Collins, C. G.*,Larkin, J. O.,Casey, G.,Whelan, M. C.,Cashman, J.,Murphy, J.,Soden, D.,Vejda, S.,McKenna, S.,Kiely, B.,Collins, J. K.,Barrett, J.,Aarons, S.,O'Sullivan, G. C.;
2006
December
Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors
Validated
()
Optional Fields
13
1212
1061
711061
Gene therapy-induced expression of immunostimulatory molecules at tumor cell level may evoke antitumor immune mechanisms by recruiting and enhancing viability of antigen-processing cells and specific tumoricidal lymphocytes. The antitumor efficacy of a plasmid, coding for granulocyte-macrophage colony-stimulating factor (GM-CSF) and the B7-1 costimulatory immune molecule, delivered into growing solid tumors by electroporation was investigated. Murine fibrosarcomas (JBS) growing in Balb/C mice (
0929-1903 (Print) 0929-19
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16874363http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16874363
Grant Details