Clarke, G; O'Mahony, SM; Hennessy, AA; Ross, P; Stanton, C; Cryan, JF; Dinan, TG;

2009

December

Behavioural Brain Research

Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood.

Published

WOS: 26 ()

205

1

319

321

The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders.

10.1016/j.bbr.2009.07.008