Clarke G, O'Mahony SM, Cryan JF, Dinan TG;

2009

April

Human Psychopharmacology

Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?

Published

WOS: 30 ()

24

3

217

223

Verapamil is a calcium channel blocker that also inhibits the P-glycoprotein (Pgp) membrane transporter. We have found that administration of verapamil with a recognised antidepressant improves clinical outcome in previously treatment resistant cases despite the fact that verapamil does not possess inherent antidepressant activity. In this study we examined the hypothesis that the antidepressant-like effects of verapamil are mediated through its blockade of the Pgp transporter in the blood brain barrier (BBB).

10.1002/hup.1008