Gosselin, RD; O'Connor, RM; Tramullas, M; Julio-Pieper, M; Dinan, TG; Cryan, JF;

2010

March

Gastroenterology

Riluzole Normalizes Early-Life Stress-induced Visceral Hypersensitivity in Rats: Role of Spinal Glutamate Reuptake Mechanisms.

Validated

Altmetric: 1 ()

The molecular basis underlying visceral hypersensitivity in functional irritable bowel syndrome remains elusive, resulting in poor treatment effectiveness. Because alterations in spinal non-neuronal (astrocytic) glutamate reuptake are suspected to participate in chronic pain, we asked whether such processes occur in visceral hypersensitivity.

10.1053/j.gastro.2010.03.003