Peer-Reviewed Journal Details
Mandatory Fields
O'Mahony, SM; Bulmer, DC; Coelho, AM; Fitzgerald, P; Bongiovanni, C; Lee, K; Winchester, W; Dinan, TG; Cryan, JF;
Neurogastroenterology and Motility
5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction.
WOS: 51 ()
Optional Fields
Irritable bowel syndrome (IBS) is associated with an enhanced perception to visceral stimuli and exaggerated stress response. The serotonergic neurotransmitter system has been strongly implicated as a key player in the manifestation of IBS symptomatology including visceral hypersensitivity. However the role of 5-HT(2B) receptors in visceral pain, although speculated, is currently unclear. Thus we assessed the impact of a selective 5-HT(2B) receptor antagonist, RS-127445, on visceral hypersensitivity in a model of brain gut axis dysfunction the Wistar Kyoto (WKY) rat.
Grant Details