Peer-Reviewed Journal Details
Mandatory Fields
O'Sullivan TP, Zhang H, Mander LN;
2007
August
Organic and Biomolecular Chemistry
Model studies toward the synthesis of the bioactive diterpenoid, harringtonolide.
Validated
WOS: 28 ()
Optional Fields
5
16
2627
2635
In model studies towards the synthesis of harringtonolide, the construction of the tropone moiety via arene cyclopropanation was investigated. The installation of the lactone ring was accomplished by way of a Diels-Alder cycloaddition of various indenones and a-pyones. The incorporation of the key bridge methyl group and subsequent control of its stereochemistry is also outlined.
10.1039/b707467k
Grant Details